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People with immune deficiency may not respond as well to vaccines but could still gain some protection.
Research suggests protective effect of natural infection or vaccination is likely to be persistent.
Natural immunity and vaccine responses may be weaker in people with immune suppression, so they should get their second dose promptly.
Long-lived memory immune cells continue to provide protection even after antibody levels drop.
Screening patients for autoantibodies against interferons could help predict which patients are more likely to become very sick.
Existing T cells may help account for the wide range COVID-19 symptoms.
Antibody analysis may provide guidance for developing vaccines and antibodies as treatments for COVID-19.
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